| Date | Location | Result | |
| 03-28-21 | Indianapolis, Ind. (Hinkle Fieldhouse) | #1 Gonzaga 83, #19 Creighton 65 | Box score |
| 03-22-21 | Indianapolis, Ind. (Hinkle Fieldhouse) | #19 Creighton 72, Ohio 58 | Box score |
| 03-20-21 | Indianapolis, Ind. (Lucas Oil Stadium) | #19 Creighton 63, UC Santa Barbara 62 | Box score |
| 03-13-21 | New York, N.Y. (Madison Square Garden) | Georgetown 73, #19 Creighton 48 | Box score |
| 03-12-21 | New York, N.Y. (Madison Square Garden) | #19 Creighton 59, UConn 56 | Box score |
| 03-11-21 | New York, NY (Madison Square Garden) | #19 Creighton 87, Butler 56 | Box score |
| 03-06-21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 93, Butler 73 | Box score |
| 03-03-21 | Villanova, Pa. (Finneran Pavilion) | #10 Villanova 72, #19 Creighton 60 | Box score |
| 02-27-21 | Cincinnati, Ohio (Cintas Center) | Xavier 77, #19 Creighton 69 | Box score |
| 02-24-21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 77, DePaul 53 | Box score |
| 02-13-21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 86, #5 Villanova 70 | Box score |
| 02-09-21 | Washington, D.C. (McDonough Arena) | #19 Creighton 63, Georgetown 48 | Box score |
| 02-06-21 | Milwaukee, Wis. (Fiserv Forum) | #19 Creighton 71, Marquette 68 | Box score |
| 02-03-21 | Omaha, Neb. (CHI Health Center Omaha) | Georgetown 86, #19 Creighton 79 | Box score |
| 01-30-21 | Chicago, Ill. (Wintrust Arena) | #19 Creighton 69, DePaul 62 | Box score |
| 01-27-21 | Newark, N.J. (Prudential Center) | #19 Creighton 85, Seton Hall 81 | Box score |
| 01-23-21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 74, #23 Connecticut 66 | Box score |
| 01-20-21 | Omaha, Neb. (CHI Health Center Omaha) | Providence 74, #19 Creighton 70 | Box score |
| 01-16-21 | Indianapolis, Ind. (Hinkle Fieldhouse) | Butler 70, #19 Creighton 66 (OT) | Box score |
| 01-09-21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 97, St. John's 79 | Box score |
| 01-06-21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 89, Seton Hall 53 | Box score |
| 01-02-21 | Providence, R.I. (Alumni Hall) | #19 Creighton 67, Providence 65 | Box score |
| 12-23-20 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 66, #22 Xavier 61 | Box score |
| 12-20-20 | Mansfield, Conn. (Gampel Pavilion) | #19 Creighton 76, UConn 74 (OT) | Box score |
| 12-17-20 | Queens, N.Y. (Carnesecca Arena) | #19 Creighton 94, St. John's 76 | Box score |
| 12-14-20 | Omaha, Neb. (CHI Health Center Omaha) | Marquette 89, #19 Creighton 84 | Box score |
| 12-11-20 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 98, Nebraska 74 | Box score |
| 12-08-20 | Lawrence, Kan. (Allen Fieldhouse) | #5 Kansas 73, #19 Creighton 72 | Box score |
| 12-04-20 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 93, Kennesaw St. 58 | Box score |
| 12-01-20 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 94, Omaha 67 | Box score |
| 11-29-20 | Omaha, Neb. (CHI Health Center Omaha) | #19 Creighton 69, North Dakota St. 58 | Box score |