| Date | Location | Result | |
| 03/27/22 | Greensboro, N.C. (Greensboro Coliseum) | South Carolina 80, Creighton 50 | Box score |
| 03/25/22 | Greensboro, N.C. (Greensboro Coliseum) | Creighton 76, #10 Iowa State 68 | Box score |
| 03/20/22 | Iowa City, Iowa (Carver-Hawkeye Arena) | Creighton 64, #8 Iowa 62 | Box score |
| 03/18/22 | Iowa City, Iowa (Carver-Hawkeye Arena) | Creighton 84, Colorado 74 | Box score |
| 03/05/22 | Uncasville, Conn. (Mohegan Sun Arena) | Seton Hall 66, Creighton 65 | Box score |
| 02/27/22 | Omaha, Neb. (D.J. Sokol Arena) | DePaul 90, Creighton 84 | Box score |
| 02/20/22 | South Orange, N.J. (Walsh Gymnasium) | Creighton 97, Seton Hall 91 (2OT) | Box score |
| 02/18/22 | Queens, N.Y. (Carnesecca Arena) | Creighton 107, St. John's 59 | Box score |
| 02/13/22 | Omaha, Neb (D.J. Sokol Arena) | Creighton 96, Butler 49 | Box score |
| 02/11/22 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 68, Xavier 47 | Box score |
| 02/06/22 | Milwaukee, Wis. (Al McGuire Center) | Marquette 50, Creighton 47 | Box score |
| 02/04/22 | Chicago, Ill. (Wintrust Arena) | Creighton 77, DePaul 68 | Box score |
| 02/02/22 | Omaha, Neb. (D.J. Sokol Arena) | #10 Connecticut 76, Creighton 56 | Box score |
| 01/28/22 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 95, Providence 71 | Box score |
| 01/23/22 | Bryn Mawr, Pa. (Finneran Pavillion) | Villanova 74, Creighton 64 | Box score |
| 01/21/22 | Washington, DC (McDonough Arena) | Creighton 80, Georgetown 70 | Box score |
| 01/19/22 | Indianapolis, Ind. (Hinkle Fieldhouse) | Creighton 95, Butler 44 | Box score |
| 01/16/22 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 86, St. John's 80 | Box score |
| 01/14/22 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 83, Seton Hall 60 | Box score |
| 01/09/22 | Mansfield, Conn. (Gampel Pavilion)_ | #10 Connecticut 63, Creighton 55 | Box score |
| 01/07/22 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 62, Marquette 45 | Box score |
| 01/02/22 | Cincinnati, Ohio (Cintas Center) | Creighton 67, Xavier 51 | Box score |
| 12/21/21 | Fayetteville, Ark. (Bud Walton Arena) | Creighton 81, Arkansas 72 | Box score |
| 12/19/21 | Providence, R.I. (Mullaney Gymnasium) | Creighton 71, Providence 56 | Box score |
| 12/16/21 | Omaha, Neb. (D.J. Sokol Arena) | South Dakota 73, Creighton 71 | Box score |
| 12/12/21 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 69, Arizona State 62 | Box score |
| 12/05/21 | Omaha, Neb (D.J. Sokol Arena) | Creighton 72, Villanova 58 | Box score |
| 12/03/21 | Omaha, Neb. (CHI Health Center) | Creighton 64, Georgetown 38 | Box score |
| 11/27/21 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 79, UNI 72 | Box score |
| 11/21/21 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 67, South Dakota State 55 | Box score |
| 11/17/21 | Lincoln, Neb.(Pinnacle Bank Arena) | Nebraska 67, Creighton 62 | Box score |
| 11/13/21 | Omaha, Neb (D.J. Sokol Arena) | Creighton 71, Omaha 51 | Box score |
| 11/10/21 | Des Moines, Iowa (Knapp Center) | Drake 82, Creighton 79 | Box score |