| Date | Location | Result | |
| 03/19/22 | Fort Worth, Texas (Dickies Arena) | #3 Kansas 79, Creighton 72 | Box score |
| 03/17/22 | Fort Worth, Texas (Dickies Arena) | Creighton 72, San Diego State 69 (OT) | Box score |
| 03/12/22 | New York, NY (Madison Square Garden) | #8 Villanova 54, Creighton 48 | Box score |
| 03/11/22 | New York, N.Y. (Madison Square Garden) | Creighton 85, #11 Providence 58 | Box score |
| 03/10/22 | New York, NY (Madison Square Garden) | Creighton 74, Marquette 63 | Box score |
| 03/05/22 | Omaha, Neb. (CHI Health Center Omaha) | Seton Hall 65, Creighton 60 | Box score |
| 03/02/22 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 64, #18 Connecticut 62 | Box score |
| 02/26/22 | Providence, R.I. (Dunkin' Donuts Center) | #11 Providence 72, Creighton 51 | Box score |
| 02/23/22 | Queens, NY (Carnesecca Arena) | Creighton 81, St. John's 78 | Box score |
| 02/20/22 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 83, Marquette 82 | Box score |
| 02/17/22 | Chicago, Ill. (Wintrust Arena) | Creighton 71, DePaul 59 | Box score |
| 02/14/22 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 88, Georgetown 77 | Box score |
| 02/12/22 | Washington, DC (Capital One Arena) | Creighton 80, Georgetown 66 | Box score |
| 02/08/22 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 54, Butler 52 | Box score |
| 02/04/22 | Newark, N.J. (Prudential Center) | Seton Hall 74, Creighton 55 | Box score |
| 02/01/22 | Hartford, Conn. (XL Center) | Creighton 59, #17 Connecticut 55 | Box score |
| 01/29/22 | Omaha, Neb. (CHI Health Center Omaha) | #21 Xavier 74, Creighton 64 | Box score |
| 01/26/22 | Indianapolis, Ind. (Hinkle Fieldhouse) | Butler 72, Creighton 55 | Box score |
| 01/22/22 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 60, DePaul 47 | Box score |
| 01/19/22 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 87, St. John's 64 | Box score |
| 01/15/22 | Cincinnati, Ohio (Cintas Center) | #17 Xavier 80, Creighton 73 | Box score |
| 01/05/22 | Bryn Mawr, Pa. (Finneran Pavilion) | #19 Villanova 75, Creighton 41 | Box score |
| 01/01/22 | Milwaukee, Wis. (Fiserv Forum) | Creighton 75, Marquette 69 (2OT) | Box score |
| 12/17/21 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 79, #9 Villanova 59 | Box score |
| 12/14/21 | Omaha, Neb. (CHI Health Center Omaha) | Arizona State 58, Creighton 57 | Box score |
| 12/11/21 | Sioux Falls, SD (Sanford Pentagon) | Creighton 83, #24 BYU 71 | Box score |
| 12/04/21 | Omaha, Neb. (CHI Health Center Omaha) | #19 Iowa State 64, Creighton 58 | Box score |
| 11/30/21 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 80, North Dakota State 55 | Box score |
| 11/27/21 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 70, SIU Edwardsville 65 | Box score |
| 11/22/21 | St. Thomas, U.S. Virgin Islands | Creighton 66, Southern Illinois 64 | Box score |
| 11/21/21 | St. Thomas, U.S. Virgin Islands | Colorado State 95, Creighton 81 | Box score |
| 11/19/21 | St. Thomas, U.S. Virgin Islands | Creighton 78, Brown 57 | Box score |
| 11/16/21 | Lincoln, Neb. (Pinnacle Bank Arena) | Creighton 77, Nebraska 69 | Box score |
| 11/11/21 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 51, Kennesaw State 44 | Box score |
| 11/09/21 | Omaha, Neb. (CHI Health Center Omaha) | Creighton 90, Arkansas-Pine Bluff 77 | Box score |