| Date | Location | Result | |
| 12/03/21 | Omaha, Neb. | Kansas 3, Creighton 1 (25-13,26-24,19-25,25-22) | Box score |
| 12/02/21 | Omaha, Neb. | Creighton 3, Ole Miss 0 (25-21,25-15,25-13) | Box score |
| 11/27/21 | Milwaukee, Wis. | Creighton 3, Marquette 0 (25-20,25-22,25-20) | Box score |
| 11/26/21 | Milwaukee, Wis. | Creighton 3, DePaul 0 (25-16,25-15,25-18) | Box score |
| 11/21/21 | Omaha, Neb. | Creighton 3, St. John's 0 (25-12,26-24,25-20) | Box score |
| 11/19/21 | Omaha, Neb. | Creighton 3, Seton Hall 0 (25-16,25-13,25-8) | Box score |
| 11/13/21 | Villanova, Pa. | Creighton 3, Villanova 0 (25-11,25-15,25-18) | Box score |
| 11/12/21 | Washington, DC | Creighton 3, Georgetown 0 (25-13,25-15,25-14) | Box score |
| 11/07/21 | Omaha, Neb. | Creighton 3, Butler 1 (25-22,25-12,22-25,25-17) | Box score |
| 11/05/21 | Omaha, Neb. | Creighton 3, Xavier 0 (25-18,25-22,25-22) | Box score |
| 10/30/21 | Chicago, Ill. | Creighton 3, DePaul 0 (25-21,25-16,25-15) | Box score |
| 10/29/21 | Milwaukee, Wis. | Creighton 3, Marquette 1 (25-23,23-25,25-12,25-20) | Box score |
| 10/24/21 | Omaha, Neb. | Creighton 3, Villanova 0 (25-19,25-17,25-18) | Box score |
| 10/22/21 | Omaha, Neb. | Creighton 3, Georgetown 0 (25-14,25-17,25-16) | Box score |
| 10/17/21 | Providence, R.I. | Creighton 3, Providence 0 (25-17,25-22,25-14) | Box score |
| 10/16/21 | Mansfield, Conn. | UConn 3, Creighton 2 (25-17,18-25,21-25,25-22,15-12) | Box score |
| 10/10/21 | Omaha, Neb. | Creighton 3, Marquette 1 (25-20,28-26,19-25,25-16) | Box score |
| 10/08/21 | Omaha, Neb. | Creighton 3, DePaul 0 (25-20,25-23,25-23) | Box score |
| 10/02/21 | South Orange, N.J. | Creighton 3, Seton Hall 0 (26-24,25-15,25-18) | Box score |
| 10/01/21 | Queens, N.Y. | St. John's (NY) 3, Creighton 1 (25-18,23-25,27-25,25-20) | Box score |
| 09/25/21 | Cincinnati, Ohio | Creighton 3, Xavier 0 (25-11,25-22,25-16) | Box score |
| 09/24/21 | Indianapolis, Ind. | Creighton 3, Butler 1 (25-16,25-22,23-25,25-19) | Box score |
| 09/18/21 | Wichita, Kan. | Creighton 3, Wichita St. 0 (26-24,25-23,25-18) | Box score |
| 09/18/21 | Wichita, Kan. | Creighton 3, South Dakota 0 (25-17,25-14,25-18) | Box score |
| 09/17/21 | Wichita, Kan. | Creighton 3, Wyoming 0 (25-19,25-10,25-19) | Box score |
| 09/11/21 | Omaha, Neb. | Creighton 3, Omaha 0 (25-17,25-18,25-16) | Box score |
| 09/11/21 | Omaha, Neb. | Creighton 3, Illinois 1 (25-18,25-16,25-27,33-31) | Box score |
| 09/10/21 | Omaha, Neb. | Creighton 3, SMU 0 (25-13,25-12,25-22) | Box score |
| 09/08/21 | Omaha, Neb. | Nebraska 3, Creighton 0 (25-14,25-22,25-16) | Box score |
| 09/04/21 | Lexington, Ky | Creighton 3, UNI 0 (25-20,25-21,25-11) | Box score |
| 09/04/21 | Lexington, KY | Creighton 3, Kentucky 0 (25-19,25-22,27-25) | Box score |
| 09/03/21 | Lexington, Ky. | Creighton 3, Southern California 2 (25-19,25-21,18-25,19-25,15-13) | Box score |
| 08/28/21 | Columbia, Mo. | Creighton 3, Missouri 0 (25-21,25-10,25-13) | Box score |
| 08/27/21 | Columbia, Mo. | Creighton 3, Saint Louis 0 (25-15,25-20,25-16) | Box score |
| 08/27/21 | Columbia, Mo. | Creighton 3, Kansas City 0 (25-23,25-13,25-12) | Box score |